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Fluoride acts as a cumulative toxin that has an affect on bone mineral metabolism. The development of osteo-fluorosis, which is increasing globally, is dependent on the total amount of ingested fluoride. Studies have also shown that levels of 4-10 ppm in drinking water causes progressive loss of cartilage, in various joints as well as crippling deformities regardless of .other variables.

Fluoride can cause lesions in the kidneys, and excessive retention of fluoride due to renal (kidney) insufficiency.. Acute renal failure may results from accidental industrial exposure to fluoride, with the toxic effects to the kidneys. This results in aluminum deposition into bone because fluoride is eliminated through the kidney, . Decreased kidney function results in increasing serum fluoride, so a vicious cycle begins. The Center for Disease Control calls for a normal control range for school fluoridation systems of up to 6.5-ppm, even though there is ample evidence of the toxic renal and other effects caused by a bottled mineral water at 8.5 ppm

It may b that men may have an even greater susceptibility to the detrimental effects of fluoride on bone strength. A comparison of fluoridated and non-fluoridated areas revealed a significant increase in bone cancer among males under 30-years of age the animal model also produces bone cancers. For this reason a gender-specific physiologically based model has been developed to describe the absorption, distribution and elimination of fluoride. Testosterone deficiency is a major risk factor for male osteoporosis and fluoride use correlates with decreased testosterone levels as well as reduced sperm count and motility. It could be argued that this is the causative factor for reduced fertility rate in areas of the U.S. having fluoride levels of at least 3-ppm. That is, based on three different types of animal studies, it may be that  this decrease in the total fertility rate might be due to the amount of fluoride ingested by men.